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《Journal of Biological Chemistry》 41:29369-29381 (2013)

An Androgen Receptor-MicroRNA-29a Regulatory Circuitry in Mouse Epididymis

Ma, W.; Hu, S.; Yao, G.; Xie, S.; Ni, M.; Liu, Q.; Gao, X.; Zhang, J.; Huang, X.; Zhang, Y.

Abstract:

Background: Abnormally up-regulated miR-29a was associated with several diseases, so miR-29a repression is important for homeostasis. Results: MiR-29a was repressed by androgen system and inversely inhibited AR expression by targeting IGF1 and CDC42/p85α-p53 pathway in mouse epididymis. Conclusion: There is an androgen receptor-miR-29a regulatory circuitry in mouse epididymis. Significance: The mutual repression between miR-29a and AR may be important for epididymal development and functions.