联系人:客服
电话:025-58641580
传真:025-58641500
邮箱:services@nbri-nju.com
QQ:800089984

文献详情

   

《Brain Research》 0:82-90 (2015)

Trio gene is required for mouse learning ability

Zong, Wen; Liu, Shuoyang; Wang, Xiaotong; Zhang, Jian; Zhang, Tingting; Liu, Ziyi; Wang, Dongdong; Zhang, Aizhen; Zhu, Minsheng; Gao, Jiangang

Abstract:

Trioisaguaninenucleotideexchangefactorwithmultipleguaninenucleotideexchange factordomains.Trioregulatescytoskeletondynamicsandactinremodelingandisinvolved in cellmigrationandaxonalguidanceinneuronaldevelopment.ThenullalleleoftheTrio geneledtoembryoniclethality,andTrionullembryosdisplayedaberrantorganizationin severalregionsofthebrainatE18.5,includinghippocampus.Nestin-Trio