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《The FASEB Journal》 10:3720-3732 (2010)

Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis

Yang, L.; Zhao, L.; Gan, Z.; He, Z.; Xu, J.; Gao, X.; Wang, X.; Han, W.; Chen, L.; Xu, T.; Li, W.; Liu, Y.

Abstract:

Mammalian RNA editing catalyzed by adenosine deaminases acting on RNA (ADARs) ADAR1 and ADAR2 plays pivotal roles in the brain through functional modifications of neurotransmitter receptors and ion channels. We have demonstrated previously that RNA editing by ADAR2 is regulated metabolically in pancreatic