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《Journal of Leukocyte Biology》 1:17-26 (2014)

Epigenetically modulated LRRC33 acts as a negative physiological regulator for multiple Toll-like receptors

Su, X.; Mei, S.; Liang, X.; Wang, S.; Liu, J.; Zhang, Y.; Bao, Y.; Chen, Y.; Che, Y.; Chunhua Zhao, R.; Zhang, Z.; Yang, R.

Abstract:

The members of a LRR family play crucial roles in the activation of innate and adaptive immune responses. We reported previously that LRRC33, a transmembrane protein of the LRR family, might potentially affect TLRmediated activity. Here, we demonstrate that LRRC33 is a negative physiological regulator for multiple TLRs. Lrrc33