众多的科研人员利用我们制作的模型小鼠进行了相关研究,并发表了众多文献。
以下列举了2008至2012年发表的部分文献:
Liu TF, Tang JJ, Li PS, Shen Y, Li JG, Miao HH, Li BL, Song BL.Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis. Cell Metab. 2012 Aug 8;16(2):213-25.
Wu QF, Yang L, Li S, Wang Q, Yuan XB, Gao X, Bao L, Zhang X, Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration. Cell. 2012 Jun 22;149(7):1549-64
Jiang B, Zhao W, Yuan J, Qian Y, Sun W, et al. (2012) Lack of Cul4b, an E3 Ubiquitin Ligase Component, Leads to Embryonic Lethality and Abnormal Placental Development. PLoS ONE 7(5): e37070.
Yang H, Shi L, Wang B-A, Liang D, Zhong C, Liu W, et al. Generation of Genetically Modified Mice by Oocyte Injection of Androgenetic Haploid Embryonic Stem Cells. Cell. 2012 Apr 27;149(3):605–17.
Tian C et al., "Foxg1 has an essential role in postnatal development of the dentate gyrus." J Neurosci 2012 Feb 29;32(9):2931-49
Xu J, Qi X, Gong J, Yu M, Zhang F, et al. (2012) Fstl1 Antagonizes BMP Signaling and Regulates Ureter Development. PLoS ONE 7(4): e32554.
Gu P, et al., Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse. Genesis. 2012 May;50(5):429-36
Geng Y, Dong Y, Yu M, Zhang L, Yan X, Sun J, Qiao L, Geng H, Nakajima M, Furuichi T, Ikegawa S, Gao X, Chen YG, Jiang D, Ning W, Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7058-63
Li KC, Wang F, Zhong YQ, Lu YJ, Wang Q, Zhang FX, Xiao HS, Bao L, Zhang X. Reduction of follistatin-like 1 in primary afferent neurons contributes to neuropathic pain hypersensitivity. Cell Res. 2011 Apr; 21(4):697-9. Epub 2011 Mar 22.
Li KC et al., "Follistatin-like 1 suppresses sensory afferent transmission by activating Na+,K+-ATPase." Neuron 2011 Mar 10;69(5):974-87
Wu, D. et al. Overexpression of SIRT1 in Mouse Forebrain Impairs Lipid/Glucose Metabolism and Motor Function. PLoS One. 2011;6(6):e21759
Zhou, H. et al.Attenuation of cardiac dysfunction by HSPA12B in endotoxin-induced sepsis in mice through a PI3K-dependent mechanism. Cardiovascular research.2011 Jan 1;89(1): 109-18
Peng YJ et al., "Trio is a key guanine nucleotide exchange factor coordinating regulation of the migration and morphogenesis of granule cells in the developing cerebellum." J Biol Chem 2010 Aug 6;285(32):24834-44
Wang X, Tang J, Xing L, Shi G, Ruan H, Gu X, Liu Z, Wu X, Gao X, Xu Y. Interaction of MAGED1 with nuclear receptors affects circadian clock function. EMBO J. 2010;29(8):1389–1400.
Wen J et al., "Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice." J Biol Chem 2010 Apr 2;285(14):11023-30
Zhang X., Min X., Li C., Benjamin I. J., Qian B., Zhang X., Ding Z., Gao X., Yao Y., Ma Y., Cheng Y., Liu L. (2010). Involvement of reductive stress in the cardiomyopathy in transgenic mice with cardiac-specific overexpression of heat shock protein 27. Hypertension 55, 1412–1417.
Tang Li et al., 2009-Oct Liver sinusoidal endothelial cell lectin, LSECtin, negatively regulates hepatic T-cell immune response., Gastroenterology 137(4):1498-508.e1-5
You W, Min X, Zhang X, Qian B, Pang S, Ding Z, Li C, Gao X, Di R, Cheng Y, et al. Cardiac-specific expression of heat shock protein 27 attenuated endotoxin-induced cardiac dysfunction and mortality in mice through a PI3K/Akt-dependent mechanism. Shock. 2009 Jul; 32(1):108-17.
He WQ et al., "Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice." Gastroenterology 2008 Aug;135(2):610-20